Uncombable Hair Syndrome

In addition to having one of the coolest names ever attributed by the medical community, uncombable hair syndrome, or UHS, makes for a rare structural anomaly caused mainly by three protein-encoding genes—namely PADI3, TCHH, and TGM3. It can be uncomfortable, but it’s not dangerous and typically disappears before puberty.

Another interesting aspect of UHS is that it’s one of the rarest medical conditions documented. According to MedlinePlus, only about 100 cases of UHS were ever found. The condition needs to affect at least 50% of one’s scalp shafts to be clinically apparent.